PathophysiologyBLOOD COMPONENTS


   A. Circulation Disorders

          a. Thrombosis

          b. Emoblisme

          c. Arteriosclerosis

          d. Ischemia and Infarction

   A. Bleeding disorders
   2. Clotting disorders
Thrombosis
• Definition: The process of formation of blood clots / coagulum of blood vessels
• blood coagulum = thrombus
• Differences with hematoma (bruise) à a clot that forms outside the vascular system.
• Hematoma à pd clot outside the vascular system of human life
• Meanwhile, when the clot was found on a dead man called post mortem clot
• Clinical effects of thrombosis may be a blockage à hemostasis
• As a result of continued occlusion à-pengatu would impede the normal circulation of the vascular bed.
• Factors that affect the:

          A. Vascular system

          2. Blood flow / circulation

          3. Clotting mechanism
Factor system of blood vessels
• The system of blood vessels have endothelial cells lining is soft and slippery
• As a result à platelets and fibrin is not easily attached
• So that thrombus formation can be avoided
Factor of blood flow
• Blood flow in the circulation has a pretty heavy flow and regular à the peripheral resistance
• As a result of heavy blood flow caused platelets will not thrown to the surface of blood vessel walls
Factor clotting mechanism
• normal clotting mechanism within the normal body has a mechanism of regulation and control
• This involves the body's chemical balance
• So if the mechanisms of regulation and control to walk normally would prevent thrombus
Conclusion
• Formation of a clot / thrombus is not normal circumstances based on the three's are:

   A. Wall and the lining of blood vessels are abnormal.
   2. Abnormalities in the circulation / blood flow
   3. Enhancement of blood coagulation
• The cause of most à factors of blood flow and arterial wall
• It depends also on the artery or vein
• Arterial pressure à dg flow and arterial wall at high speed with a rather thick and not easily change shape
• The cause of arterial thrombus à pd lining and walls of the arteries
• Venous blood flow is à flow with low pressure and relatively low speeds.
• The walls of the vein is thin enough to easily change shape
• The cause of venous thrombus à result of reduced blood flow.